Immunohistochemical markers for arthritis in psoriasis.
Thursday, July 7th, 1994
Immunohistochemical markers for arthritis in psoriasis.
Ann Rheum Dis. 1994 Jul;53(7):450-4
Authors: Veale DJ, Barnes L, Rogers S, FitzGerald O
OBJECTIVES–To examine the immunohistological features in the involved skin of patients with psoriatic arthritis (PA) (n = 15), compared with those in involved skin from patients with psoriasis but no arthritis (n = 5), and with a group with normal skin (n = 4), to identify markers for arthritis in psoriasis. METHODS–Skin was obtained from patients by 6 mm punch biopsy and normal skin was provided by the department of plastic surgery. Samples were stained with monoclonal antibodies against T cells (CD3, CD8, CD4, CD45Ro), B cells (CD20), macrophages (mac387), vascular endothelium (FVIII-related antigen) and a Langerhan’s cell marker (p155). The number of cells/vessels staining with each monoclonal antibody was calculated and serial sections of skin were examined to estimate the presence of DR+ keratinocytes. RESULTS–There were significantly more CD45Ro T-cells and blood vessels in patients with psoriatic arthritis compared with both psoriasis alone, and with normal controls (p
PMID: 7944617 [PubMed - indexed for MEDLINE]
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